Web2 de nov. de 2015 · PFKFB3 was demonstrated to be a hypoxia inducible gene that was stimulated through HIF-1 interaction with the consensus hypoxia response element site in its promoter region . However, the relationship between PFKFB3 and chronic inflammation is … Web17 de set. de 2024 · Apelin-13 Attenuates Lipopolysaccharide-Induced Inflammatory Responses and Acute Lung Injury by Regulating PFKFB3-Driven Glycolysis Induced by NOX4-Dependent ROS. Yafei Yuan 1 Department of Respiratory and Critical Care Medicine, Nanfang Hospital, ... (HIF-α) in LPS-treated BMDMs was markedly increased compared …
Purification and Characterization of Hypoxia-inducible Factor 1 (∗ ...
Web18 de mar. de 2024 · HIF-1a was stabilised by 4 and 6 h OGD in PC12 cells and 2 h OGD onwards in primary neurons. A panel of hypoxic genes were upregulated by the OGD treatments depending on the duration. ... Pfkfb3 was significantly upregulated by OGD at 4 h (~7-fold), 6 h (~15-fold), and 12 h (~17-fold). Web4 de jun. de 2024 · Silencing of PFKFB3 in tumor cells reduces tumor cell growth, invasion, intravasation and metastasis and improves chemotherapy of primary and metastatic … ireland and belgium
Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in ...
WebMeanwhile, PFKFB3 could further enhance the phosphorylation level of ULK1 and promote autophagy in PASMCs. Moreover, intratracheal administration of adeno-miR-26a-5p markedly alleviated right ventricular hypertrophy and pulmonary vascular remodeling in hypoxia-induced PAH rat models in vivo. Web8 de ago. de 2013 · Although the expression of most of these regulatory enzymes is increased by hypoxia , the PFKFB3 family member has been found to be a direct transcriptional target of HIF-1α , to be stabilized by the loss of the tumor suppressor PTEN via suppressive effects on APC/Cdh1-mediated ubiquitination , and to be activated by … WebHypoxia-inducible factor 1 (HIF-1) is a DNA-binding protein that activates erythropoietin (Epo) gene transcription in Hep3B cells subjected to hypoxia or cobalt chloride treatment. HIF-1 DNA binding activity is also induced by hypoxia or cobalt in non-Epo-producing cells, suggesting a general role for HIF-1 in hypoxia signal transduction and transcriptional … ireland and mercho