Cytoplasmic phospholipase a2
WebMar 23, 2005 · Our focus is on the Ca 2+-sensitive form, referred to as cytoplasmic phospholipase A 2 α (cPLA 2 α), which is ubiquitously expressed in most tissues and … WebJun 18, 1999 · We further show that MIF regulates cytosolic phospholipase A 2 activity via a protein kinase A and ERK dependent pathway and that the glucocorticoid suppression of cytokine-induced cytoplasmic phospholipase A2 activity and arachidonic acid release can be reversed by the addition of recombinant MIF. These studies indicate that the …
Cytoplasmic phospholipase a2
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WebCytoplasmic phospholipase A2 metabolites play a critical role in pulmonary tumor metastasis in mice. This study demonstrates that cPLA(2) metabolites play critical roles … WebDec 8, 2024 · Activation of phospholipase A2 (PLA2) is an essential prerequisite for GPVI stimulated thromboxane A2 (TXA2) generation that induces paracrine platelet activation …
WebOct 1, 2024 · Among them, cytoplasmic phospholipase A2 (cPLA2), the key enzyme of the pro-inflammatory mediator, was the most significantly down-regulated protein. And enriched KEGG pathway shown that PPAR-γ pathway was most involved. Taxifolin significantly reduced p-cPLA2 and increased PPAR-γ protein level in keratinocytes and … WebGeneral Function. Phospholipase a2 activity. Specific Function. Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. Pfam Domain Function.
WebMay 15, 1993 · Cytoplasmic phospholipase A2 activity and gene expression are stimulated by tumor necrosis factor: dexamethasone blocks the induced synthesis. W G … WebMay 5, 2005 · Introduction. Lipid requirements of the mammal are met by dietary intake and de novo synthesis; the omega-6 fatty acids (ω-6 FAs) are essential since they cannot be synthesized by mammals and must be supplied in the diet. Linoleic acid (LA) and its product, arachidonic acid (AA) are transformed into prostaglandins (PG) and thromboxanes (TX) …
WebDec 8, 2024 · Summary This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes.
WebCytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene. [5] [6] Function [ edit] This gene encodes a member of the cytosolic … foamy reef eulaWebCytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene. [5] [6] Function [ edit] This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. foamy shopWebOct 8, 2004 · Arachidonic acid is released from membrane phospholipids by phospholipase A2 (PLA2). Several types of PLA2 are expressed in human cells. Among them … foamy seaWebPhospholipase A2s constitute a wide group of lipid-modifying enzymes which display a variety of functions in innate immune responses. In this work, we utilized mass spectrometry-based lipidomic approaches to investigate the action of Asp-49 Ca2+-dependent secreted phospholipase A2 (sPLA2) (MT-III) and Lys-49 sPLA2 (MT-II), two … foamy saliva while sleepingWebNov 21, 2014 · Cytosolic Phospholipase A2 Assay Kit (ab133090) can be used to determine the activity of cytosolic Phospholipase A2 (cPLA2) in purified preparations, … greenyard fresh france sasWebCytosolic phospholipase A 2 (cPLA2) is a calcium-dependent enzyme that cleaves fatty acids, such as arachidonic acid, from phospholipids by hydrolyzing the SN-2 acyl bond … foamys car wash vegasWebApr 12, 1994 · Cytoplasmic phospholipase A2 translocates to membrane fraction in human neutrophils activated by stimuli that phosphorylate mitogen-activated protein … foamy shoes