Cisplatin half-life
Web1152 rows · Jun 13, 2005 · Cisplatin has a plasma half-life of 30 minutes. The … WebFeb 16, 2024 · Warnings. Cisplatin can affect your nervous system, increase your risk of bleeding or infection, or harm your kidneys.. Call your doctor if you have a fever, mouth sores, cough, sore throat, unusual bleeding or bruising, hearing problems, numbness or tingling in your hands or feet, little or no urinating, swelling or rapid weight gain, or …
Cisplatin half-life
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Webcisplatin (Rx) Brand and Other Names: Classes: Antineoplastics, Alkylating; Antineoplastics, Platinum Analog Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths injectable... WebSep 18, 2024 · Cisplatin is a medication used to manage and treat solid tumors and hematologic malignancies. It is in the alkylating agent class of cytotoxic medications. ... Its initial half-life is approximately 20 to 30 minutes, with a terminal half-life of 24 hours. ALbumin-bound platinum undergoes slow administration of minimally five days.
WebSep 7, 2024 · A We can calculate the half-life of the reaction using Equation 14.5.3: t 1 / 2 = 0.693 k = 0.693 1.5 × 10 − 3 m i n − 1 = 4.6 × 10 2 m i n Thus it takes almost 8 h for half of the cisplatin to hydrolyze. B After 5 half-lives (about 38 h), the remaining concentration of cisplatin will be as follows: 0.053 M 2 5 = 0.053 M 32 = 0.0017 M Webfrom 50 to 100 mg/m2, plasma cisplatin half-life is approximately 30 minutes. The ratios of cisplatin to total, free (ultrafilterable) platinum in the plasma range from 0.4 to 1.1 after a dose of 100 mg/m2. Cisplatin does not undergo instantaneous and reversible binding to plasma proteins characteristic of normal drug-protein binding.
WebNov 1, 2001 · Half life of cisplatin is 43 minutes with approximately 1/4th being eliminated within the first 24 hours (90% renal clearance). For carboplatin, IV bolus injection of 375mg/m2 leads to 39mg/mL concentration of drug initially, which declines to 9 mg/mL after 2 hours. Carboplatin is excreted in the urine, but not from the renal tubules. WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often …
WebCisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced cancer that cannot be treated with other therapies, such as surgery or radiation therapy. Ovarian cancer that has spread to other parts of the body. It is used with other drugs in patients who have already had surgery ...
WebIntravenous carboplatin is rapidly cleared by the kidneys, with a 2.5 h half-life. It is exclusively eliminated by the kidneys, and is excreted in the urine essentially unchanged. Current indications. Carboplatin is used for most of the same solid cancer types as is cisplatin, including testicular, ovarian, lung, and head/neck. It is less often ... drug outlineWebDec 1, 1987 · Calculated pharmacokinetic parameters (peak concentrations, half-lives, areas under the curve) were compared with the corresponding values in patients at the … drug outreach programsWebCisplatin was found to bind to bovine erythrocyte-SOD at His19 with high selectivity as no other binding sites were identified. 83 Surprisingly, amine ligands as opposed to the chlorido ligand underwent ligand exchange reactions with His19 of SOD. ravanusa palazzinaWebMar 2, 2005 · The half-lives for total platinum and active drug were calculated by dividing 0.693 by the terminal rate constant. RESULTS Model-independent plasma ultrafiltrate and CSF pharmacokinetic variables for oxaliplatin, cisplatin and … drug overdose crisisWebAbstract. Background: Cisplatin is a highly effective and frequently used drug in the chemotherapy of solid tumours in children, but only limited data are available on the … ravanwadiWebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … drug out usti nad labemWebIn addition, the plasma elimination half-life of cisplatin is prolonged in renal failure. Caution should be exercised in patients with pre-existing renal dysfunction. Cisplatin is contraindicated in patients with serum creatinine levels greater than 0.2 mmol/L. Repeat courses are not advised until serum creatinine is below 0.14 mmol/L and/or ... ra vao